Two sample MR report

Telomere_length against aparc-a2009s rh volume G-occipital-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0104534	0.1066661	0.9228611
Weighted median	23	-0.0323897	0.0549697	0.5557080
Inverse variance weighted	23	-0.0164601	0.0407968	0.6866064
Simple mode	23	-0.0314636	0.0899799	0.7299091
Weighted mode	23	-0.0189295	0.0564971	0.7407588

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.17931	21	0.2844518
Inverse variance weighted	24.26582	22	0.3334514

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016525	0.0060285	0.7866781

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007408	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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