Two sample MR report

Telomere_length against aparc-a2009s rh volume G-insular-short

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0921396	0.1103762	0.4132392
Weighted median	23	-0.0085527	0.0554299	0.8773756
Inverse variance weighted	23	0.0136396	0.0432143	0.7522861
Simple mode	23	0.0909383	0.1046078	0.3940544
Weighted mode	23	-0.0174887	0.0586865	0.7684980

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.8906	21	0.2106512
Inverse variance weighted	27.2270	22	0.2027313

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064948	0.0062382	0.3096517

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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