Two sample MR report

Telomere_length against aparc-a2009s rh volume G-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0880332	0.1261658	0.4929824
Weighted median	23	-0.1084870	0.0567985	0.0561291
Inverse variance weighted	23	-0.0387538	0.0483750	0.4230668
Simple mode	23	-0.0900500	0.0998170	0.3767484
Weighted mode	23	-0.1028609	0.0700971	0.1564174

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.82856	21	0.0377996
Inverse variance weighted	34.11862	22	0.0477768

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030258	0.0071306	0.6756383

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010639	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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