Two sample MR report

Telomere_length against aparc-a2009s rh volume G-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1086510	0.1231104	0.3874708
Weighted median	23	-0.0281276	0.0602489	0.6406019
Inverse variance weighted	23	-0.0761165	0.0470945	0.1060404
Simple mode	23	-0.0775738	0.1150558	0.5071900
Weighted mode	23	0.0302079	0.0836989	0.7216079

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.21075	21	0.0557348
Inverse variance weighted	32.33718	22	0.0718265

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019976	0.006958	0.7768496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010961	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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