Two sample MR report

Telomere_length against aparc-a2009s rh volume G-front-inf-Triangul

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0245893	0.1337276	0.8558749
Weighted median	23	-0.0560878	0.0595385	0.3461708
Inverse variance weighted	23	-0.0546451	0.0511289	0.2851719
Simple mode	23	0.0348834	0.1153120	0.7651029
Weighted mode	23	-0.0556043	0.0647946	0.4000555

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.00553	21	0.0128694
Inverse variance weighted	38.11343	22	0.0177921

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018454	0.007558	0.8094689

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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