Two sample MR report

Telomere_length against aparc-a2009s rh volume G-front-inf-Orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0531492	0.1008454	0.6036921
Weighted median	23	-0.0250793	0.0580235	0.6655767
Inverse variance weighted	23	-0.0078297	0.0388466	0.8402647
Simple mode	23	-0.1457906	0.1040106	0.1749590
Weighted mode	23	-0.0762284	0.0617445	0.2300118

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.61128	21	0.4221989
Inverse variance weighted	21.85657	22	0.4684773

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027826	0.0056996	0.6304563

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006636	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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