Two sample MR report

Telomere_length against aparc-a2009s rh volume G-front-inf-Opercular

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1002916	0.1014585	0.3341620
Weighted median	23	-0.0886852	0.0579682	0.1260427
Inverse variance weighted	23	-0.0442128	0.0390673	0.2577570
Simple mode	23	-0.1539448	0.1126290	0.1854846
Weighted mode	23	-0.1282576	0.0762951	0.1068926

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.87677	21	0.4066408
Inverse variance weighted	22.25239	22	0.4449130

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034433	0.0057342	0.5546166

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007136	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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