Two sample MR report

Telomere_length against aparc-a2009s rh volume G-cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0189273	0.1528978	0.9026586
Weighted median	23	0.0003264	0.0667018	0.9960959
Inverse variance weighted	23	0.0144634	0.0583767	0.8043197
Simple mode	23	-0.0765966	0.1313597	0.5657522
Weighted mode	23	-0.0349347	0.1026794	0.7369100

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.68579	21	0.0004034
Inverse variance weighted	49.68817	22	0.0006461

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002741	0.0086415	0.9749975

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015098	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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