Two sample MR report

Telomere_length against aparc-a2009s rh volume G-cingul-Post-ventral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0052090	0.1070242	0.9616414
Weighted median	23	0.0271439	0.0571284	0.6346876
Inverse variance weighted	23	0.0315267	0.0409304	0.4411508
Simple mode	23	-0.0494015	0.1019602	0.6328078
Weighted mode	23	0.0673487	0.0635027	0.3003933

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.34268	21	0.2767527
Inverse variance weighted	24.42541	22	0.3253321

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016159	0.0060488	0.7919625

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007601	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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