Two sample MR report

Telomere_length against aparc-a2009s rh volume G+S-transv-frontopol

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1434579	0.1211343	0.2495306
Weighted median	23	-0.1693308	0.0585119	0.0038042
Inverse variance weighted	23	-0.0863005	0.0465370	0.0636749
Simple mode	23	0.0895993	0.1563798	0.5724822
Weighted mode	23	-0.2544012	0.0959108	0.0145458

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.18665	21	0.0706073
Inverse variance weighted	31.57688	22	0.0849013

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035095	0.0068463	0.6135725

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011064	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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