Two sample MR report

Telomere_length against aparc-a2009s rh volume G+S-subcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2418236	0.1256070	0.0678501
Weighted median	23	-0.1029234	0.0624058	0.0990941
Inverse variance weighted	23	-0.0927682	0.0498174	0.0625796
Simple mode	23	-0.0943009	0.0917915	0.3154247
Weighted mode	23	-0.0981465	0.0746148	0.2019288

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.53096	21	0.0406512
Inverse variance weighted	36.18471	22	0.0290104

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0091521	0.0070991	0.2113523

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012692	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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