Two sample MR report

Telomere_length against aparc-a2009s rh volume G+S-paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1096629	0.1050002	0.3081717
Weighted median	23	-0.0274315	0.0576680	0.6343029
Inverse variance weighted	23	-0.0024474	0.0412460	0.9526841
Simple mode	23	-0.0323835	0.0885662	0.7181248
Weighted mode	23	-0.0288610	0.0662733	0.6674536

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.43017	21	0.3214782
Inverse variance weighted	24.80313	22	0.3065818

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006583	0.0059343	0.279842

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007517	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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