Two sample MR report

Telomere_length against aparc-a2009s rh volume G+S-occipital-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0753599	0.1023222	0.4695773
Weighted median	23	0.0531113	0.0538398	0.3239024
Inverse variance weighted	23	0.0499463	0.0391331	0.2018430
Simple mode	23	0.0246722	0.0827725	0.7684450
Weighted mode	23	0.0445018	0.0606418	0.4707911

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.24982	21	0.3852386
Inverse variance weighted	22.32695	22	0.4405245

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015604	0.005783	0.7899305

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007266	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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