Two sample MR report

Telomere_length against aparc-a2009s rh volume G+S-frontomargin

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1531241	0.0994076	0.1384051
Weighted median	23	0.0418931	0.0526464	0.4261811
Inverse variance weighted	23	0.0267742	0.0388461	0.4906735
Simple mode	23	0.0196373	0.0891528	0.8276949
Weighted mode	23	0.0291131	0.0615090	0.6406516

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.04798	21	0.582062
Inverse variance weighted	20.95466	22	0.523542

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0077579	0.0056183	0.181853

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006494	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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