Two sample MR report

Telomere_length against aparc-a2009s rh volume G+S-cingul-Mid-Post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0216322	0.1145401	0.8520147
Weighted median	23	-0.0449768	0.0555486	0.4181214
Inverse variance weighted	23	-0.0200337	0.0438928	0.6480856
Simple mode	23	-0.1250389	0.0954908	0.2038984
Weighted mode	23	-0.0671860	0.0630420	0.2981010

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.88133	21	0.1435492
Inverse variance weighted	28.08868	22	0.1727608

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025583	0.0064735	0.6966881

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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