Two sample MR report

Telomere_length against aparc-a2009s rh volume G+S-cingul-Mid-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0488963	0.1153909	0.6760606
Weighted median	23	-0.0346384	0.0580678	0.5508302
Inverse variance weighted	23	-0.0306433	0.0440861	0.4870061
Simple mode	23	0.0201430	0.1125763	0.8596319
Weighted mode	23	-0.0366257	0.0731130	0.6213838

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.29728	21	0.1319199
Inverse variance weighted	28.33707	22	0.1647777

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011207	0.0065216	0.865202

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008775	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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