Two sample MR report

Telomere_length against aparc-a2009s rh volume G+S-cingul-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0687815	0.1194403	0.5708270
Weighted median	23	0.0027463	0.0587617	0.9627233
Inverse variance weighted	23	-0.0609764	0.0456072	0.1812250
Simple mode	23	0.0703837	0.1137515	0.5424355
Weighted mode	23	0.0328692	0.0873443	0.7102858

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.31927	21	0.0857577
Inverse variance weighted	30.32654	22	0.1107413

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004792	0.0067505	0.9440761

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009936	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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