Two sample MR report

Telomere_length against aparc-a2009s rh volume G-Ins-lg+S-cent-ins

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2166518	0.1225039	0.0914975
Weighted median	23	-0.1032615	0.0633648	0.1031789
Inverse variance weighted	23	-0.0280722	0.0497880	0.5728672
Simple mode	23	0.1889837	0.1656739	0.2662622
Weighted mode	23	-0.1542810	0.0883259	0.0946340

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.89432	21	0.0600080
Inverse variance weighted	36.14198	22	0.0293191

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0115789	0.0069237	0.1092894

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001111	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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