Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-temporal-transverse

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0290238	0.0994090	0.7731797
Weighted median	23	-0.0186515	0.0549263	0.7341782
Inverse variance weighted	23	0.0074771	0.0388467	0.8473685
Simple mode	23	-0.0412800	0.0868687	0.6393286
Weighted mode	23	-0.0385006	0.0617994	0.5396940

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.41803	21	0.5583428
Inverse variance weighted	19.57715	22	0.6094712

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022411	0.0056183	0.6939967

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005944	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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