Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-temporal-sup

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1103346	0.1149247	0.3479497
Weighted median	23	0.0937740	0.0569049	0.0993718
Inverse variance weighted	23	0.0732288	0.0469172	0.1185687
Simple mode	23	0.0757897	0.0981426	0.4481888
Weighted mode	23	0.0514857	0.0745377	0.4969573

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.06886	21	0.1382091
Inverse variance weighted	32.09340	22	0.0758176

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0112707	0.0064952	0.0973551

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010801	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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