Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-temporal-inf

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0317946	0.0994070	0.7522479
Weighted median	23	0.0343387	0.0535988	0.5217427
Inverse variance weighted	23	0.0273995	0.0388456	0.4805963
Simple mode	23	0.0517989	0.0991043	0.6064277
Weighted mode	23	0.0205322	0.0672281	0.7629244

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.96341	21	0.7717036
Inverse variance weighted	16.38190	22	0.7964905

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036345	0.0056182	0.5246988

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005115	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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