Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-subparietal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1710715	0.1201313	0.1691258
Weighted median	23	0.0045926	0.0586224	0.9375556
Inverse variance weighted	23	0.0047219	0.0485468	0.9225167
Simple mode	23	0.0110394	0.1063961	0.9183021
Weighted mode	23	0.0071389	0.0860522	0.9346332

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.67098	21	0.0793107
Inverse variance weighted	34.36218	22	0.0451115

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0107938	0.0067896	0.1268333

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010416	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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