Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-suborbital

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0285704	0.1116494	0.8005229
Weighted median	23	-0.0670664	0.0607896	0.2699165
Inverse variance weighted	23	-0.0010647	0.0427110	0.9801122
Simple mode	23	-0.1186710	0.1047544	0.2694732
Weighted mode	23	-0.1186710	0.0949873	0.2246717

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.49210	21	0.1883034
Inverse variance weighted	26.59699	22	0.2269341

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018196	0.0063102	0.7758995

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000806	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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