Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-precentral-sup-part

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1664101	0.1136929	0.1580900
Weighted median	23	0.0641655	0.0622315	0.3025043
Inverse variance weighted	23	0.0271359	0.0468089	0.5621060
Simple mode	23	0.1454525	0.1049327	0.1795911
Weighted mode	23	0.0856968	0.0887416	0.3446961

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.47134	21	0.1557911
Inverse variance weighted	31.94568	22	0.0783268

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0118838	0.0064257	0.0785242

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009828	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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