Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-precentral-inf-part

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1495537	0.1022605	0.1584159
Weighted median	23	-0.0435501	0.0574206	0.4481876
Inverse variance weighted	23	-0.0257864	0.0406177	0.5255221
Simple mode	23	0.1183126	0.1045662	0.2700444
Weighted mode	23	-0.0658392	0.0664053	0.3322338

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.22398	21	0.3867030
Inverse variance weighted	24.05362	22	0.3444253

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075993	0.0057795	0.2027337

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007422	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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