Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-postcentral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1612416	0.0994059	0.1197105
Weighted median	23	-0.0341534	0.0549869	0.5345212
Inverse variance weighted	23	-0.0128273	0.0388453	0.7412382
Simple mode	23	0.1219232	0.1182428	0.3136852
Weighted mode	23	-0.0958076	0.0734655	0.2056743

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.37152	21	0.8038591
Inverse variance weighted	18.00235	22	0.7058490

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0091127	0.0056182	0.1197254

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005488	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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