Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-pericallosal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0924167	0.1515154	0.5484394
Weighted median	23	-0.0778812	0.0568882	0.1709918
Inverse variance weighted	23	-0.0383969	0.0580529	0.5083486
Simple mode	23	-0.1629026	0.0949235	0.1001855
Weighted mode	23	-0.0734576	0.0591113	0.2270619

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.78787	21	0.0005366
Inverse variance weighted	49.13641	22	0.0007663

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033168	0.0085633	0.7024112

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015183	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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