Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-parieto-occipital

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1409330	0.0994064	0.1709333
Weighted median	23	-0.0094853	0.0553821	0.8640107
Inverse variance weighted	23	0.0244569	0.0388455	0.5289601
Simple mode	23	0.0388496	0.0973084	0.6935642
Weighted mode	23	-0.0283220	0.0621850	0.6532509

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.51316	21	0.8465649
Inverse variance weighted	17.78020	22	0.7189379

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0101549	0.0056182	0.0850329

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005508	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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