Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-orbital-med-olfact

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2178457	0.1358679	0.1237897
Weighted median	23	0.0295541	0.0580834	0.6108767
Inverse variance weighted	23	0.0109829	0.0551486	0.8421447
Simple mode	23	0.0314889	0.0989140	0.7532246
Weighted mode	23	0.0454642	0.0669878	0.5044094

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.23149	21	0.0092087
Inverse variance weighted	44.34256	22	0.0032128

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0127012	0.0076789	0.1129892

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001346	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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