Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-orbital-lateral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0321482	0.0994091	0.7495959
Weighted median	23	-0.0171748	0.0525432	0.7437658
Inverse variance weighted	23	-0.0143392	0.0388468	0.7120364
Simple mode	23	0.0101382	0.0853900	0.9065686
Weighted mode	23	-0.0079240	0.0641048	0.9027468

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.49494	21	0.6175042
Inverse variance weighted	18.53281	22	0.6739719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010935	0.0056184	0.8475578

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005657	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8