Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-orbital-H-Shaped

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0337273	0.1169446	0.7758650
Weighted median	23	0.0679810	0.0555564	0.2210877
Inverse variance weighted	23	0.0651581	0.0447388	0.1452791
Simple mode	23	0.0627645	0.0934315	0.5087240
Weighted mode	23	0.0382046	0.0652049	0.5638951

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.06328	21	0.1124904
Inverse variance weighted	29.18127	22	0.1397578

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019299	0.0066095	0.7731643

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009695	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8