Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-oc-temp-med+Lingual

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2610577	0.1235738	0.0467852
Weighted median	23	-0.0458581	0.0569464	0.4206551
Inverse variance weighted	23	0.0232646	0.0537415	0.6650880
Simple mode	23	-0.0128908	0.0942352	0.8924374
Weighted mode	23	-0.0436670	0.0598741	0.4735043

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.45288	21	0.0526470
Inverse variance weighted	42.10826	22	0.0060649

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0174571	0.006984	0.020797

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012867	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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