Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-oc-temp-lat

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0005484	0.1351805	0.9968017
Weighted median	23	-0.0239371	0.0626370	0.7023457
Inverse variance weighted	23	-0.0687236	0.0519786	0.1861173
Simple mode	23	-0.0512394	0.1082887	0.6407502
Weighted mode	23	-0.0365574	0.1226878	0.7685213

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.83775	21	0.0102625
Inverse variance weighted	39.39292	22	0.0127175

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004186	0.0076402	0.5895423

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012882	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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