Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-oc-sup+transversal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1896102	0.1126446	0.1071337
Weighted median	23	-0.0454988	0.0591691	0.4419162
Inverse variance weighted	23	-0.0239156	0.0455470	0.5995304
Simple mode	23	-0.0876003	0.1257805	0.4934382
Weighted mode	23	-0.0993116	0.0694187	0.1665913

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.9673	21	0.1719383
Inverse variance weighted	30.2466	22	0.1125930

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0101737	0.0063665	0.1249779

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000928	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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