Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-oc-middle+Lunatus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1846255	0.0994054	0.0773498
Weighted median	23	-0.0603573	0.0545130	0.2682035
Inverse variance weighted	23	-0.0028181	0.0388453	0.9421666
Simple mode	23	-0.0436882	0.0873620	0.6219823
Weighted mode	23	-0.0734310	0.0626062	0.2533780

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.77561	21	0.7821233
Inverse variance weighted	19.72354	22	0.6003284

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0111629	0.0056182	0.0601304

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005978	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8