Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-occipital-ant

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0778373	0.1008112	0.4486522
Weighted median	23	-0.0309535	0.0546660	0.5712378
Inverse variance weighted	23	-0.0395588	0.0388463	0.3085157
Simple mode	23	-0.0381514	0.0860768	0.6619305
Weighted mode	23	-0.0349133	0.0602627	0.5682375

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.59706	21	0.4230394
Inverse variance weighted	21.77206	22	0.4735627

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023503	0.0056976	0.68415

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006911	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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