Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-intrapariet+P-trans

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1545992	0.1254150	0.2313100
Weighted median	23	-0.0165398	0.0610682	0.7865128
Inverse variance weighted	23	-0.0161445	0.0494954	0.7442869
Simple mode	23	0.0289199	0.1053349	0.7862224
Weighted mode	23	0.0057348	0.0942793	0.9520456

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.42849	21	0.0416766
Inverse variance weighted	35.71820	22	0.0325450

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085012	0.0070883	0.2437544

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010875	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8