Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-interm-prim-Jensen

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0525599	0.0994143	0.6025600
Weighted median	23	-0.0586719	0.0518044	0.2573965
Inverse variance weighted	23	-0.0730160	0.0388480	0.0601720
Simple mode	23	-0.0302140	0.0808307	0.7121363
Weighted mode	23	-0.0717603	0.0638440	0.2731305

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.55734	21	0.9508049
Inverse variance weighted	11.60731	22	0.9649670

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001256	0.0056187	0.8252759

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004588	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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