Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-front-sup

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0034659	0.1120522	0.9756163
Weighted median	23	0.0555950	0.0575172	0.3337535
Inverse variance weighted	23	0.0685063	0.0432736	0.1133995
Simple mode	23	0.1485895	0.1136726	0.2046528
Weighted mode	23	0.0823399	0.0789227	0.3081395

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.68333	21	0.1815825
Inverse variance weighted	27.30202	22	0.1999794

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044191	0.0063329	0.4929605

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009216	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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