Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-front-middle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0800696	0.137047	0.5652767
Weighted median	23	0.0265996	0.061495	0.6653425
Inverse variance weighted	23	0.0136026	0.053006	0.7974692
Simple mode	23	0.0569248	0.104743	0.5922701
Weighted mode	23	0.0356977	0.076893	0.6470288

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.91618	21	0.0076132
Inverse variance weighted	40.96422	22	0.0083222

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0057515	0.0077456	0.4659812

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001245	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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