Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-front-inf

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0219204	0.1132276	0.8483527
Weighted median	23	0.0072701	0.0553822	0.8955604
Inverse variance weighted	23	0.0459996	0.0432842	0.2879031
Simple mode	23	0.0236402	0.0975537	0.8107695
Weighted mode	23	-0.0012507	0.0633356	0.9844229

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.24594	21	0.1628601
Inverse variance weighted	27.31519	22	0.1994990

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014784	0.0063993	0.819526

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008702	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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