Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-collat-transv-post

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1225736	0.0994084	0.2311890
Weighted median	23	-0.0381369	0.0552704	0.4901903
Inverse variance weighted	23	0.0041560	0.0388464	0.9148015
Simple mode	23	-0.0559022	0.0962359	0.5672203
Weighted mode	23	-0.0358723	0.0614414	0.5652625

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.52211	21	0.6790128
Inverse variance weighted	19.44023	22	0.6180097

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077812	0.0056184	0.180602

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005894	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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