Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-collat-transv-ant

Date: 23 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0643332 0.1055459 0.5487133
Weighted median 23 -0.0259511 0.0571649 0.6498511
Inverse variance weighted 23 -0.0357469 0.0403794 0.3760086
Simple mode 23 -0.0663336 0.0969683 0.5010708
Weighted mode 23 -0.0168186 0.0728662 0.8195920

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.67452 21 0.3090948
Inverse variance weighted 23.77212 22 0.3592869

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0017552 0.0059652 0.7714643

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.000746 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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