Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-circular-insula-sup

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0196824	0.1183581	0.8695153
Weighted median	23	0.0259099	0.0577003	0.6534008
Inverse variance weighted	23	0.0055461	0.0452459	0.9024419
Simple mode	23	-0.0243871	0.0989151	0.8075459
Weighted mode	23	0.0256317	0.0670269	0.7058270

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.77011	21	0.0967058
Inverse variance weighted	29.84613	22	0.1222525

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001549	0.0066893	0.8191158

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000905	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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