Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-circular-insula-inf

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0089178	0.1383523	0.9492157
Weighted median	23	0.1148078	0.0608853	0.0593435
Inverse variance weighted	23	0.0209494	0.0528905	0.6920393
Simple mode	23	0.0875020	0.1100923	0.4352173
Weighted mode	23	0.0875020	0.0733961	0.2458883

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.67931	21	0.0061418
Inverse variance weighted	40.78586	22	0.0087381

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018338	0.0078193	0.8168484

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012447	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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