Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-circular-insula-ant

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0021155	0.0994091	0.9832228
Weighted median	23	-0.0321415	0.0584336	0.5822838
Inverse variance weighted	23	-0.0408399	0.0388467	0.2931158
Simple mode	23	-0.1256594	0.0942981	0.1963099
Weighted mode	23	-0.0379678	0.0627861	0.5515537

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.32104	21	0.6286072
Inverse variance weighted	18.54141	22	0.6734493

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026375	0.0056184	0.6435967

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005954	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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