Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-cingul-Marginalis

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2550553	0.1287366	0.0608120
Weighted median	23	-0.0055358	0.0635581	0.9305935
Inverse variance weighted	23	-0.0381494	0.0529272	0.4710393
Simple mode	23	0.0988117	0.1041327	0.3529788
Weighted mode	23	0.0288539	0.1020285	0.7799725

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.22430	21	0.0266753
Inverse variance weighted	40.84422	22	0.0085999

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0133182	0.007276	0.0814159

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012667	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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