Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-central

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1819393	0.1334152	0.1871004
Weighted median	23	-0.0142504	0.0590148	0.8091893
Inverse variance weighted	23	0.0002120	0.0535382	0.9968400
Simple mode	23	-0.0302801	0.1069138	0.7796566
Weighted mode	23	-0.0380638	0.0651816	0.5651845

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.82800	21	0.0134996
Inverse variance weighted	41.79091	22	0.0066255

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.011184	0.0075403	0.1528659

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012663	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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