Two sample MR report

Telomere_length against aparc-a2009s rh thickness S-calcarine

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2073873	0.0994054	0.0493343
Weighted median	23	-0.0060120	0.0559150	0.9143757
Inverse variance weighted	23	0.0188050	0.0388453	0.6283153
Simple mode	23	0.0151836	0.0998116	0.8804764
Weighted mode	23	-0.0080405	0.0674650	0.9062139

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.12116	21	0.8168238
Inverse variance weighted	21.23200	22	0.5064424

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0138882	0.0056182	0.0220707

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006505	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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