Two sample MR report

Telomere_length against aparc-a2009s rh thickness Pole-temporal

Date: 23 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0254632 0.1061258 0.8127080
Weighted median 23 -0.0406774 0.0575043 0.4793298
Inverse variance weighted 23 -0.0450444 0.0405566 0.2667169
Simple mode 23 -0.1254323 0.1065887 0.2518560
Weighted mode 23 -0.0211427 0.0826921 0.8005734

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.93545 21 0.2961968
Inverse variance weighted 23.98124 22 0.3482134

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0012023 0.005998 0.8430591

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007674 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8